ALEX: Improving SIP Support in Systems with Multiple Network Addresses

The successful and increasingly adopted session initiation protocol (SIP) does not adequately support hosts with multiple network addresses, such as dual-stack (IPv4-IPv6) or IPv6 multi-homed devices. This paper presents the Address List Extension (ALEX) to SIP that adds effective support to systems with multiple addresses, such as dual-stack hosts or multi-homed IPv6 hosts. ALEX enables IPv6 transport to be used for SIP messages, as well as for communication sessions between SIP user agents (UAs), whenever possible and without compromising compatibility with ALEX-unaware UAs and SIP servers

Providing End-to-End Connectivity to SIP User Agents Behind NATs

The widespread diffusion of private networks in SOHO scenarios is fostering an increased deployment of Network Address Translators (NATs). The presence of NATs seriously limits end-to-end connectivity and prevents protocols like the Session Initiation Protocol (SIP) from working properly. This document shows how the Address List Extension (ALEX), which was originally developed to provide dual-stack and multi-homing support to SIP, can be used, with minor modifications, to ensure end-to-end connectivity for both media and signaling flows, without relying on intermediate relay nodes whenever it is possibl

Design Methodologies and Architecture Solutions for High-Performance Interconnects

ABSTRACT In Deep Sub-Micron (DSM) technologies, interconnects play a crucial role in the correct functionality and largely impact the performance of complex System-on-Chip (SoC) designs. For technologies of 0.25µm and below, wiring capacitance dominates gate capacitance, thus rapidly increasing the interconnect-induced delay. Moreover, the coupling capacitance becomes a significant portion of the on-chip total wiring capacitance, and coupling between adjacent wires cannot be considered as a second-order effect any longer. As a consequence, the traditional top-down design methodology is ineffective, since the actual wiring delays can be computed only after layout parasitic extraction, when the physical design is completed. Fixing all the timing violations often requires several time-consuming iterations of logical and physical design, and it is essentially a trial-and-error approach. Increasingly tighter time-to-market requirements dictate that interconnect parasitics must be taken into account during all phases of the design flow, at different level of abstractions. However, given the aggressive technology scaling trends and the growing design complexity, this approach will only temporarily ameliorate the interconnect problem. We believe that in order to achieve gigascale designs in the nanometer regime, a novel design paradigm, based on new forms of regularity and newly created IP (Intellectual Property) blocks must be developed, to provide a direct path from system-level architectural exploration to physical implementation

La Leyenda de Alejandro según el Šāhnāme de Ferdowsī. La transmisión desde la versión griega hasta la versión persa

El presente estudio analiza la versión persa de la Leyenda de Alejandro en el Šāhnāme de Ferdowsī para encontrar las posibles fuentes y responder a la pregunta cómo esta obra originalmente en griego entró en el mundo persa

Effect of Biofertilizers Application on Soil Biodiversity and Litter Degradation in a Commercial Apricot Orchard

The aim of the present experiment was to determine if the supply of biofertilizers could differently stimulate the native microbiota, thus determining different patterns of organic material decomposition processes. The microbial composition of soil and litter was investigated by next generation sequencing using a metabarcoding approach. The chemical structure of the decomposing litterbags was investigated through the TG-DTA analysis and NIR spectroscopy. The study was conducted in an apricot orchard in Italy, and two different type of biofertilizers (AMF and Trichoderma spp.) were compared to unfertilized control over one year. Bacteria and fungi in soil, 162 days from litter deposition, evidenced differentiated clusters for control and both biofertilizers; on the other hand, only fungal composition of litterbags was modified as a consequence of Trichoderma spp. supply; no effect was observed in the bacterial community of litterbags. NIR and TG-DTA analysis evidenced a significant change over time of the chemical composition of litterbags with a faster degradation as a consequence of Trichoderma spp. supply testified by a higher degradation coefficient (1.9) than control (1.6) and AMF (1.7). The supply of biofertilizers partially modified the bacteria community of soil, while Trichoderma spp. Influenced the fungal community of the litter. Moreover, Trichoderma spp. Evidenced a faster and higher degradation of litter than AMF-biofertilizers, laying the foundation for an efficient use in orchard

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

Molecular targeted drugs are clinically effective anti-cancer therapies. However, tumours treated with single agents usually develop resistance. Here we use colorectal cancer (CRC) as a model to study how the acquisition of resistance to EGFR-targeted therapies can be restrained. Pathway-oriented genetic screens reveal that CRC cells escape from EGFR blockade by downstream activation of RAS-MEK signalling. Following treatment of CRC cells with anti-EGFR, anti-MEK or the combination of the two drugs, we find that EGFR blockade alone triggers acquired resistance in weeks, while combinatorial treatment does not induce resistance. In patient-derived xenografts, EGFR-MEK combination prevents the development of resistance. We employ mathematical modelling to provide a quantitative understanding of the dynamics of response and resistance to these single and combination therapies. Mechanistically, we find that the EGFR-MEK Combo blockade triggers Bcl-2 and Mcl-1 downregulation and initiates apoptosis. These results provide the rationale for clinical trials aimed at preventing rather than intercepting resistance